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	lipoid nephrosis

Disease ID	1112
Disease	lipoid nephrosis
Definition	A kidney disease with no or minimal histological glomerular changes on light microscopy and with no immune deposits. It is characterized by lipid accumulation in the epithelial cells of KIDNEY TUBULES and in the URINE. Patients usually show NEPHROTIC SYNDROME indicating the presence of PROTEINURIA with accompanying EDEMA.
Synonym	change disease minimal change diseases minimal change diseases, minimal change glomerulonephritis minimal changes glomerulonephritis minimal disease nils disease, minimal change diseases, minimal change foot process disease glomerulopathies, minimal change glomerulopathy, minimal change idiopathic minimal change nephrotic syndrome light negative glomerulonephritis lipid nephrosis lipoid nephroses mcd - minimal change disease mcgn - minimal change glomerulonephritis mcn - minimal change nephropathy minimal change disease minimal change disease (disorder) minimal change diseases minimal change glomerulonephritis minimal change glomerulopathy minimal change nephropathies minimal change nephropathy nephropathies, minimal change nephropathy, minimal change nephroses, lipoid nephrosis lipoid nephrosis, lipoid nephrosis, lipoid [disease/finding] nil disease
DOID	DOID:10966
UMLS	C0027721
MeSH	D009402
SNOMED-CT	SNOMEDCT_US_2016_09_01:44785005
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:28) C0027726 \| nephrotic syndrome \| 16 C0017661 \| iga nephropathy \| 3 C0022658 \| nephropathy \| 3 C0033687 \| proteinuria \| 3 C0409974 \| lupus erythematosus \| 1 C0221238 \| mesangial proliferative glomerulonephritis \| 1 C0019196 \| hepatitis c infection \| 1 C0035078 \| renal failure \| 1 C0019829 \| hodgkin disease \| 1 C0812413 \| malignant pleural mesothelioma \| 1 C0019196 \| hepatitis c \| 1 C0027697 \| nephritis \| 1 C0018213 \| graves' disease \| 1 C0042769 \| virus infection \| 1 C1377913 \| pleural mesothelioma \| 1 C0205969 \| malignant thymoma \| 1 C0017668 \| focal segmental glomerulosclerosis \| 1 C0024141 \| systemic lupus erythematosus \| 1 C0022672 \| acute tubular necrosis \| 1 C0022660 \| acute renal failure \| 1 C0242647 \| malt lymphoma \| 1 C0334634 \| mantle cell lymphoma \| 1 C0021400 \| influenza \| 1 C0019163 \| hepatitis b \| 1 C1527336 \| sjogren's syndrome \| 1 C0019158 \| hepatitis \| 1 C0032533 \| polymyalgia rheumatica \| 1 C0027707 \| interstitial nephritis \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:1) 4868 \| NPHS1 \| CTD_human
Inferring Gene	Entrez_id \| Symbol \| Resource(Total Genes:5) 3105 \| HLA-A \| CIPHER 3106 \| HLA-B \| CIPHER 4842 \| NOS1 \| CIPHER 4846 \| NOS3 \| CIPHER 4868 \| NPHS1 \| CTD_human
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:60) 130013 \| ACMSD \| 1.952 \| DISEASES 87 \| ACTN1 \| 1.657 \| DISEASES 88 \| ACTN2 \| 1.744 \| DISEASES 91056 \| AP5B1 \| 1.033 \| DISEASES 722 \| C4BPA \| 1.399 \| DISEASES 9332 \| CD163 \| 1.429 \| DISEASES 930 \| CD19 \| 1.569 \| DISEASES 23607 \| CD2AP \| 1.072 \| DISEASES 958 \| CD40 \| 1.266 \| DISEASES 959 \| CD40LG \| 4.296 \| DISEASES 960 \| CD44 \| 1.733 \| DISEASES 170482 \| CLEC4C \| 1.115 \| DISEASES 1378 \| CR1 \| 1.649 \| DISEASES 286204 \| CRB2 \| 2.195 \| DISEASES 1490 \| CTGF \| 1.133 \| DISEASES 1649 \| DDIT3 \| 1.424 \| DISEASES 1785 \| DNM2 \| 1.03 \| DISEASES 6993 \| DYNLT1 \| 1.09 \| DISEASES 954 \| ENTPD2 \| 3.407 \| DISEASES 2172 \| FABP6 \| 1.691 \| DISEASES 389549 \| FEZF1 \| 1.405 \| DISEASES 342184 \| FMN1 \| 1.077 \| DISEASES 26762 \| HAVCR1 \| 2.274 \| DISEASES 10525 \| HYOU1 \| 1.35 \| DISEASES 3586 \| IL10 \| 1.703 \| DISEASES 64423 \| INF2 \| 1.558 \| DISEASES 348120 \| LINC01193 \| 1.235 \| DISEASES 4010 \| LMX1B \| 1.911 \| DISEASES 4094 \| MAF \| 1.27 \| DISEASES 4153 \| MBL2 \| 1.427 \| DISEASES 10724 \| MGEA5 \| 2.05 \| DISEASES 25974 \| MMACHC \| 1.38 \| DISEASES 4600 \| MX2 \| 1.167 \| DISEASES 4868 \| NPHS1 \| 4.472 \| DISEASES 7827 \| NPHS2 \| 4.937 \| DISEASES 8828 \| NRP2 \| 1.35 \| DISEASES 5005 \| ORM2 \| 1.974 \| DISEASES 340990 \| OTOG \| 2.639 \| DISEASES 56034 \| PDGFC \| 1.16 \| DISEASES 23556 \| PIGN \| 3.225 \| DISEASES 5329 \| PLAUR \| 2.137 \| DISEASES 5420 \| PODXL \| 3.803 \| DISEASES 5498 \| PPOX \| 1.027 \| DISEASES 6139 \| RPL17 \| 3.156 \| DISEASES 6275 \| S100A4 \| 1.08 \| DISEASES 5265 \| SERPINA1 \| 1.389 \| DISEASES 462 \| SERPINC1 \| 1.199 \| DISEASES 6693 \| SPN \| 1.026 \| DISEASES 6696 \| SPP1 \| 1.545 \| DISEASES 11346 \| SYNPO \| 4.939 \| DISEASES 129685 \| TAF8 \| 1.725 \| DISEASES 7018 \| TF \| 1.139 \| DISEASES 7096 \| TLR1 \| 1.472 \| DISEASES 7099 \| TLR4 \| 1.292 \| DISEASES 7124 \| TNF \| 1.016 \| DISEASES 7225 \| TRPC6 \| 2.1 \| DISEASES 7422 \| VEGFA \| 1.572 \| DISEASES 7490 \| WT1 \| 2.425 \| DISEASES 9213 \| XPR1 \| 1.515 \| DISEASES 23051 \| ZHX3 \| 3.112 \| DISEASES
Locus	(Waiting for update.)

Disease ID	1112
Disease	lipoid nephrosis
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:17) HP:0000100 \| Nephrosis \| 17 HP:0001919 \| Acute renal failure \| 3 HP:0000093 \| Proteinuria \| 3 HP:0000112 \| Nephropathy \| 3 HP:0001970 \| Interstitial nephritis \| 1 HP:0000097 \| focal glomerulosclerosis \| 1 HP:0002664 \| Neoplasia \| 1 HP:0100002 \| Pleural mesothelioma \| 1 HP:0000083 \| Renal insufficiency \| 1 HP:0100615 \| Neoplasm of the ovary \| 1 HP:0008682 \| Renal tubular necrosis \| 1 HP:0200123 \| Chronic liver inflammation \| 1 HP:0000123 \| Nephritis \| 1 HP:0012597 \| Heavy proteinuria \| 1 HP:0012189 \| Hodgkin disease \| 1 HP:0012115 \| Liver inflammation \| 1 HP:0002725 \| Systemic lupus erythematosus \| 1

Disease ID	1112
Disease	lipoid nephrosis
Manually Symptom	UMLS \| Name(Total Manually Symptoms:9) C1963137 \| hydrocephalus C1962974 \| chylothorax C1611280 \| allergy C0154251 \| lipid disorders C0032461 \| polycythemia C0031154 \| peritonitis C0030920 \| peptic ulcer C0027726 \| nephrotic syndrome C0020473 \| hyperlipemia
Text Mined Symptom	(Waiting for update.)

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

Text Mining Genotype(Total Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:1)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs1570360	21978756	7422	VEGFA	umls:C0027721	BeFree	Finally, we have not proved any significant influence of the polymorphisms at positions -2578 C/A and -1154 G/A of the vascular endothelial growth factor gene promoter on the progression of chronic glomerulonephritides even though our study suggests a negative effect of CC genotype of -2578 C/A polymorphism on the clinical course of minimal change disease/focal segmental glomerulosclerosis.	0.001085767	2011	VEGFA	6	43770093	A	G

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Disease ID	1112
Disease	lipoid nephrosis
Case	(Waiting for update.)

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